An atypical pigmented lesion on the nose—Answer
نویسندگان
چکیده
PCSCC is a variant of invasive squamous cell carcinoma, with less than 20 cases reported, to our knowledge, in the English literature [1,2]. PCSCC had been more often reported to occur in the oral mucosa and conjunctiva [3]. Pigmentation is probably due to cytokines secreted by tumoral cells that stimulate melanocytes to produce melanin [4]. In some cases, PCSCC may be the malignant progression of a pigmented actinic keratosis or a pigmented Bowen’s disease [4]. The clinical appearance of PCSCC is considered nonspecific, with differential diagnoses including other benign and malignant skin lesions such as melanoacanthoma, seborrheic keratosis, melanoma, pigmented basal cell carcinoma, pigmented basosquamous carcinoma and pigmented adnexal tumors [3,5]. The dermatoscopic features of our case were unspecific and no algorithm was useful for a correct diagnosis [6,7]. As previously reported by Rosendahl and colleagues, malignancy was considered on the basis of the “chaos and clues” algorithm: there was “chaos” (asymmetry, structureless global pattern) and the clues of “few discrete blue-grey blotches with rather ill-defined edges (blue)” and “atypical vessels” [6,7]. Indeed, the scaly center and the pink-white halo were suggestive of a keratotic lesion, even though the diagnosis of PCSCC was not initially considered. On the basis of our and previous reports, PCSCC should be considered when dealing with a pigmented lesion characterized by an unspecific dermoscopic pattern with the features of diffuse blue-gray pigmentation, scaling, polymorphic vessels and radial structures [1,6,8,9]. Congratulations to Dr. Paschal Dsouza, who was the first to send us the correct answer!
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2014